Endocrine Abstracts

Myocardin-related transcription factor (MRTF)-A is a Rho signaling-responsive co-activator of serum response factor (SRF). In this study we investigated roles of MRTF-A in the process underlying vascular diseases by using two different mouse models of vascular diseases. MRTF-A expression was significantly higher in the wire-injured femoral arteries of wild-type mice and in the atherosclerotic aortic tissues of ApoE−/− mice than in healthy control tissues...